As terrorism is increasing internationally, interest in the security of nuclear facilities is also increasing. Accordingly, the IAEA has published various Nuclear Security Series, which are security requirements documents, and presents various security measures. As a result of these IAEA efforts, the effectiveness of nuclear security is increasing internationally. However, it is not easy to find guidelines on nuclear security design considering efficiency. In general, effectiveness should indeed have a high priority in nuclear security. However, efficiency should be considered when considering the economic sustainability of nuclear energy and establishing balanced nuclear security systems. In order to consider efficiency, it is necessary to be able to compare input and output. In this study, after presenting a methodology for quantifying effort(input) and effectiveness(output) and obtaining efficiency with the ratio, a pilot application of response measures against insider threats was applied to the design. Expert judgment was used in quantifying qualitative effort and effectiveness, and the Analytic Hierarchy Process technique was used for reasonable statistical processing of this expert judgment. As a result of the pilot application, this study is expected to reasonably set the application priority among numerous protection measures as it can evaluate the effectiveness of each protective measure considering the characteristics of the national security environment and technology.