The timely detection of clandestine nuclear facilities through satellite imagery (SI) analysis is one of the greatest challenges faced by IAEA’s SGIS satellite imagery processing capabilities. INL, through DHS, is currently applying machine learning (ML) to existing SI databases to find critical infrastructure facilities across the USA, with primary focus placed on identifying critical predecessor and successor facilities. For example, in the case of a clandestine research reactor, predecessor and successor facilities would include steel forging plants, water treatment services, and specialized logistic distribution centers (inter alia). This project explores the use of available public SI datasets for ML, applying mature and proven classification algorithms and scene change detection software to satellite imagery. This capability addresses IAEA’s needs to detect undeclared nuclear materials and activities within a State while encompassing the entire nuclear fuel cycle.