The International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) was established in 2000 with the goal of ensuring a sustainable nuclear energy supply to help meet 21st century global energy needs. INPRO’s activities focus on the key concepts of global nuclear energy sustainability and the development of long-range nuclear energy strategies so that nuclear energy is and remains available to meet national energy needs in interested IAEA Member States. INPRO examines issues of vital importance to the nuclear material management community in its six areas of assessment that include safety and economics plus the nuclear materials management relevant areas of proliferation resistance, waste management, environment, and infrastructure. These last four areas touch on fuel cycle needs and nuclear material use, transport and handling both in a State and globally. The INPRO task “Global scenarios” creates global and regional nuclear energy scenarios, using developed scientific-technical analysis tools that lead to a global vision of sustainable nuclear energy development in the current century and beyond that can provide focus for nuclear material management needs, too. The collaborative project KIND implemented in 2014 - 2018 under INPRO task “Global scenarios” provides an approach for comparative evaluation of nuclear energy system/scenario options based on a limited set of problem-specific key indicators and the state-of-the-art judgment aggregation and sensitivity/uncertainty analysis methods. This paper explains the approach developed within the KIND project and highlights its application potential for nuclear energy system and fuel cycle planning.